Browsing by Author "Utkan, T"
Now showing items 1-11 of 11
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Aging impairs nitric oxide-mediated relaxant responses of rabbit corporal smooth muscle
Utkan, T; Yildirim, S; Sarioglu, Y; Yildiz, F; Yildirim, K (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2002)Aging has been reported to cause impotence, the mechanism of which is unknown. Therefore, we investigated the effect of aging on electrical stimulation-induced neurogenic, carbachol-induced, endothelium-dependent, and ... -
Effect of deferoxamine and sympathectomy on vasospasm following subarachnoid hemorrhage
We examined the effects of subarachnoid hemorrhage (SAH) and treatment with deferoxamine (DFO) or sympathectomy on vascular smooth muscle function, as well as the underlying mechanisms involved, by recording the responses ... -
Effects of castration on adrenergic, cholinergic and nonadrenergic, noncholinergic responses of isolated corpus cavernosum from rabbit
Yildirim, MK; Yildirim, S; Utkan, T; Sarioglu, Y; Yalman, Y (BLACKWELL SCIENCE LTD, 1997)Objective To investigate the effects of castration and testosterone on the constricting effect of phenylephrine and endothelium-dependent and -independent relaxing effects of different agonists in the corpus cavernosum of ... -
Effects of deferoxamine and sympathectomy on endothelin-1-induced contraction and acetylcholine-induced relaxation following subarachnoid hemorrhage in carotid artery
Sarioglu, Y; Utkan, T; Akgun, M; Duzcan, E; Utkan, NZ (ELSEVIER SCIENCE INC, 1997)The role of endothelium-related factors in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH) has gained interest since the discovery of EDRF and of endothelin (ET-1). The effect of SAH and both ... -
Effects of exogenous testosterone on isolated rabbit corpus cavernosum penis
Yildirim, S; Utkan, T; Yildirim, K; Sarioglu, Y (ACTA PHARMACOLOGICA SINICA, 2000)AIM: To study the effects of exogenous excess of testosterone on the constricting effect of phenylephrine and endothelium-dependent and -independent relaxing effects of different:agonists in the corpus cavernosum penis ... -
Effects of experimental obstructive jaundice on contractile responses of dog isolated blood vessels: Role of endothelium and duration of bile duct ligation
Utkan, ZN; Utkan, T; Sarioglu, Y; Gonullu, NN (BLACKWELL SCIENCE ASIA, 2000)1. We examined the effects of experimental obstructive jaundice caused by bile duct ligation (BDL) on vascular smooth muscle function, as well as the underlying mechanisms involved, by recording responses to noradrenaline ... -
Effects of sympathectomy on endothelin-1 and histamine responses of rabbit carotid artery
Utkan, T; Kaya, T; Sarioglu, Y (ELSEVIER SCIENCE INC, 1997)1. The effects of chronic sympathectomy on contractile responses of rabbit common carotid artery was studied in vitro. 2. Endothelin-1 (ET-I), histamine, KCl and papaverine concentration-response curves of sympathectomized ... -
Effects of the specific phosphodiesterase inhibitors on alloxan-induced diabetic rabbit cavernous tissue in vitro
Utkan, T; Yildirim, MK; Yildirim, S; Sarioglu, Y (NATURE PUBLISHING GROUP, 2001)An experimental study was done to examine a potential role of phosphodiesterase (PDE) inhibitors in the treatment of diabetic erectile dysfunction, Relaxant effect of specific PDE inhibitors were measured in strips of ... -
Evidence of relaxant effect of omeprazole in rabbit corpus cavernosum in vitro
Sarioglu, Y; Yildirim, S; Utkan, T; Yildirim, MK; Uma, S (PERGAMON-ELSEVIER SCIENCE LTD, 2000)The present experiments were designed to investigate the effects of omeprazole, a H+-K+ ATPase inhibitor, on corporal smooth muscle tone in vitro. All spontaneous contractile activity in the corpus cavernosum was blocked ... -
Impaired contraction and relaxation in the aorta of streptozotocin-diabetic rats
Utkan, T; Sarioglu, Y; Yildirim, S (KARGER, 1998)It is known that diabetes mellitus alters the vascular responsiveness to several vasoconstrictors and vasodilators. Endothelium-derived nitric oxide is a potent endogenous nitrovasodilator, and endothelin-1 (ET-1) is a ... -
Vascular smooth muscle reactivity and endothelium derived relaxing factor in experimental obstructive jaundice
Utkan, T; Sarioglu, Y; Utkan, NZ; Gonullu, NN; Yildirim, MK (SWETS ZEITLINGER PUBLISHERS, 1996)Obstructive jaundice is associated with a predisposition to systemic hypotension and acute renal failure. Altered vascular reactivity may contribute to the development of hypotension. In this experimental study on dogs, ...